Other names: Getgo, Tazzle, Zydalis, Forzest, Tadalis, Zydalis, He-Hot, Amore, Golmal, Forzest, Popup, Taldenaxyl, Erectalis, 36 Hours, Tadacip, Tadil, Tado, Tadarich, Filda, Manforce More, Esculap, Kwiklis, Tadarich, Apcalis, Erotid, Cialis.
Manufacturer: Balkan Pharmaceuticals
Pharmaceutical name: Tadalafil
Pack: 20 tabs (20 mg/tab)
Esculap – mens health drug, this drug is also known as Cialis and is made by Balkan Pharmaceuticals.
Esculap is an oral drug that is used for treating impotence (the inability to attain or maintain a penile erection). It is in a class of drugs called phosphodiesterase inhibitors that also includes sildenafil (Viagra) and vardenafil (Levitra).
Erection of the penis is caused by the filling of the penis with blood. Filling occurs because the blood vessels that bring blood to the penis increase in size and deliver more blood to the penis, and, at the same time, the blood vessels that take blood away from the penis decrease in size and remove less blood from the penis.
Sexual stimulation that leads to an erection causes the production and release of nitric oxide in the penis. The nitric oxide causes an enzyme, guanylate cyclase, to produce cyclic guanosine monophosphate (cGMP). It is the cGMP that is primarily responsible for increasing and decreasing the size of the blood vessels carrying blood to and from the penis, respectively, and causing the erection. When the cGMP is destroyed by another enzyme, phosphodiesterase-5, the blood vessels return to their normal size, blood leaves the penis, and the erection ends. Tadalafil prevents phosphodiesterase-5 from destroying cGMP so that cGMP stays around longer. The persistence of cGMP leads to a more prolonged engorgement of the penis with blood.
Long-acting type 5 phosphodiesterase isoenzyme inhibitors are a class of drugs currently prescribed for the treatment of erectile dysfunction in males. Tadalafil Citrate was made available after the initial drug, sildenafil citrate, had been on the market for several years. While sharing many of the pharmacokinetic properties and type 5 phosphodiesterase isoenzyme inhibitory activity profiles, there are several differences in the actions of the drugs although for the most part the results experienced by the user are relatively the same. The major difference between the drugs is the active life of tadalafil citrate. By extending the active life of the drug to approximately thirty-six to forty-eight hours, this allows users to be far less restricted in their dosing protocol and, for lack of a better word, spontaneity.
For the purposes of steroid users the use of Esculap is rather limited beyond that of a “recreational” purpose. One exception to this may be once a steroid user is coming off of anabolic-androgenic steroids and have suffered a significant reduction in their ability to perform sexually and/or their sex drive. The use of drugs such as Esculap can help to alleviate some of the difficulty many have during this period of time.
Type 5 phosphodiesterase isoenzyme inhibitors such as tadalafil citrate work by causing the smooth-muscles to relax in the cavernosal arteries. This in turn allows penile vasodilation and erection to occur in response to sexual stimuli. This response allows one to achieve and maintain an erection and will help with doing so for a number of causes of the erectile dysfunction.